Here are the steps to disable the .pdb file generation
Visual Studio – Compile Options
In Visual Studio 2005, .pdb file gets generated in Debug mode and Release mode.
In debug mode it loads the entire symbol table, in Release mode it loads the key symbols.
In Release mode, the generated .pdb can be deleted very well deleted. (Because framework does not uses it)
To disable .pdb generation in Release mode, goto
Project Properties > Compile Tab > Advanced Compile Options